Is it sensible to combine backup types on a single drive?

Reader George Lai queries the following:

I have been using Time Machine for years. I am now considering adding SuperDuper and/or Carbon Copy Cloner (CCC) as additional backup tools. Can I just use these on the same external hard disk drive as where my TM backups reside or do I have to partition it?

I have a bit of philosophy to go along with the pragmatic answer. The philosophy is: “Don’t put all your eggs in one basket.” Having incrementally updated full-drive Time Machine backups on the same physical volume as drive clones seems like a fundamentally bad idea. If something goes wrong with the physical mechanism, it renders both kinds of backups bad.

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