Another replacement chemical intended to skirt BPA’s hormone-disrupting potential, may itself have troubling hormone-disrupting ways, a new study suggests.
Fluorene-9-bisphenol (BHPF), a bisphenol A-alternative used in a wide variety of products, interfered with estrogen signaling in yeast and mouse experiments, researchers reported in Nature Communications. In a yeast assay, BHPF proved capable of blocking estrogen—a female sex hormone involved in reproductive system development and pregnancy. In mice, high doses of the chemical caused pregnant females to have smaller wombs, litters, and pups.
The study provides yet another example of a BPA-alternative chemical displaying similar hormone-disrupting potential as BPA, which Ars has reported on previously.